In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
Aged black garlic, Carbon tetrachloride, D-galactosamine, Liver injury, Non-alcoholic fatty liver disease
- 1Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
- 2College of Pharmacy, Chungbuk National University, Cheongju, Korea.
- 3Novarex Co., Ltd., Ochang, Cheongwon, Chungbuk, Korea.
- 4Namhaegun Blackgarlic Co., Ltd., 176-40, Seolcheon-ro, Seolcheon-myeon, Namhae-gun, Gyeongsangnam-do, Korea.
date: 2014 Mar